Abstract: ObjectiveTo compare the early clinical efficacy of video-assisted thoracoscopic segmentectomy and lobectomy for the treatment of early-stage lung cancer. MethodsRetrospective analysis was performed using clinical data from 35 lung cancer patients at early stage. They were divided into a lobectomy group (n=17) and a segmentectomy group (n=18). The lobectomy group underwent video-assisted thoracoscopic lobectomy, while the segmentectomy group received video-assisted thoracoscopic segmentectomy. Then, both groups were compared for the operation time, intra-operative blood loss, and hospitalization stay. All patients were follow-up visited for one year to evaluate their pulmonary function. ResultsThere was no significant difference in intra-operative blood loss and hospitalization stay between the two groups (P>0.05). The lobectomy group required longer operation time than the segmentectomy group. One year after operation, patients in the segmentectomy group showed better pulmonary function than those in the lobectomy group (P<0.05). ConclusionsBoth video-assisted thoracoscopic segmentectomy and S lobectomy are safe and effective in the treatment of early-stage lung cancer in the short term. Video-assisted thoracoscopic segmentectomy is more beneficial to protect postoperative pulmonary function.