Abstract: ObjectiveTo evaluate the application of modified retroperitoneoscopic cytoreductive surgery in the treatment of metastatic renal cell carcinoma. MethodsThe operation method was improved from traditionally first treatment of the kidney pedicle to the ureter. After the ureter was cut off, the renal pedicle and free kidney was treated from the lower to the upper along the layer without vessels. A total of 80 metastatic renal cell carcinoma patients underwent the above modified retroperitoneoscopic cytoreductive surgery from January to December 2016. Their clinical data were analyzed retrospectively. ResultsThe mean operative time was (137.2±36.4) min. The mean blood loss was (80.1±28.5) ml. The mean hospitalization stay after operation was (7.0±2.3) days. There were 7 patients who needed open surgery. There were no postoperative complications. ConclusionsDuring the modified retroperitoneoscopic cytoreductive surgery, the renal pedicle can be easily exposed. The surgery is safe and effective, with less complication, which can be useful in clinical setting.