Abstract: ObjectiveTo investigate the effects of rhizoma drynariae flavones on the metabolism of serum bone alkaline phosphate, calcium and phosphorus in osteoporosis patients with dental defects and to understand its effects on bone quality and mass of the alveolar bone. MethodsA total of 46 patients were randomly divided into two groups (n=23): an observation group (Qianggu capsules) and a control group (alendronate sodium). The levels of serum bone alkaline phosphate, calcium and phosphorus were detected before administration, and 1, 3 and 6 months after administration. ResultsCompared with the observation group, the control group showed remarkably increases in serum calcium level one month after administration (P<0.05). Compared with the control, the level of serum calcium was significantly increased for the observation Group three months after administration (P<0.05). Three months after administration, the level of serum calcium was markedly higher than that before administration in the observation group (P<0.01). Furthermore, no statistical difference was found between the two groups at different time points (P>0.05). The levels of serum bone alkaline phosphate were decreased in the two groups with the extension of administration time, and remarkable decreases were found in the control group 1 month after administration (P<0.01) and in the observation group 3 months after administration (P<0.01). ConclusionsRhizoma drynariae flavones can effectively increase the level of serum calcium and decrease the level of bone alkaline phosphate in osteoporosis patients with dental defects after three months of administration, and stimulate the stability of serum bone alkaline phosphate, calcium and phosphorus, which will facilitate the improvement of bone quality and mass of the alveolar bone.