Abstract: ObjectiveTo analyze the differences in the tear of proliferative diabetic retinopathy (PDR) patients using OCULUS Keratograph. MethodsA total of 30 proliferative diabetic retinopathy patients (30 eyes) were included in a PDR group, while another 30 healthy subjects (30 eyes) were included in a control group. Their average noninvasive tear film break-up time (NIBUT-ave), noninvasive tear meniscus height (NITMH), and fluorescein tear film break-up time (FBUT) were determined. Also, the Schirmer I test (SIT) was performed. ResultsIn the PDR group, NIBUT-ave was (8.42±3.45) s, NITMH was (0.15±0.07) mm, FBUT was (7.70±3.14) s, and SIT was (7.33±2.96) mm. In the control group, NIBUT-ave was (10.70±3.20) s, NITMH was (0.19±0.05) mm, FBUT was (10.57±2.90) s, and SIT was (11.37±3.71) mm. Statistical difference was seen as to the above indicators between the two groups (P<0.01). ConclusionsThe quantity and stability of tear secreted by PDR patients was significantly lower than those of healthy subjects.