Abstract: Objective: To observe the effect of stress management on negative emotions and quality of life in CCU first episode of AMI patients. Methods: 286 CCU first episode of AMI patients were randomly divided into observation group (n=143) and control group (n=143). The control group was treated with conventional CCU, and the observation group carried out stress management on the basis of routine CCU nursing in the control group. The hospitalization time, the negative emotions (assessed by the Hospital Anxiety and Depression Scale), sleep quality (assessed by the Athens Insomnia Scale), quality of life (assessed by the Seattle Angina Questionnaire) at the time of admission and at the time of discharge were compared between two groups. Results: There were no significant difference in hospitalization time, the HADS anxiety score, HADS depression score and AIS score at the time of admission between the two groups (P > 0.05). The HADS anxiety score, HADS depression score and AIS score of the observation group were (4.67±0.79) points, (4.63±0.87) points and (2.95±1.77) points, which lower than (5.18±0.86) points, (5.21±0.95) points, (3.54±1.69) points in the control group(P < 0.05). There were no significant difference in the quality of life scores of each dimension between the two groups (P > 0.05). The quality of life scores of each dimension in the observation group were all higher than those in the control group (P < 0.05). There were no correlation between PL score, DP score with the HADS anxiety score and HADS depression score (P > 0.05). The AF score, AS score and TS score were negatively correlated with HADS anxiety score and HADS depression score (P < 0.05). Conclusion: The CCU first AMI patients with quality of life and negative emotions related to the application of stress management can effectively improve the patient’s negative emotions, thereby improving the quality of sleep and quality of life of patients.