Abstract: ObjectiveTo evaluate clinical efficacy of minocycline in different dosage forms in the treatment of chronic periodontitis, so as to provide evidence for rational treatment of chronic periodontitis. MethodsA total of 26 chronic periodontitis patients with 79 diseased teeth were enrolled in the current study. They were randomly divided into an ointment group and a gel group. All patients first underwent scaling and root planning followed by administration of minocycline ointment or gel in the periodontal pocket. The clinical effects were assess based on plaque index (PLI), sulcus bleeding index (SBI), probing depth (PD) and attachment loss (AL) at baseline, and six and twelve weeks after surgery. ResultsThere was no statistically significant difference in the above baseline indexes between the ointment group and the gel group (P>0.05). After administration, remarkable decreases were found in PLI, SBI and PD in the ointment group, compared with those in the gel group (P<0.05). No statistical difference was found in AI between the both groups (P>0.05). ConclusionsAdministration with minocycline can markedly improve the clinical idexes of chronic periodontitis, where better prognosis is found after ointment use than gel use.