Abstract: Objective To observe the effect of flurbiprofen axetil on memory impairment induced by ketamine in juvenile mice. Methods Mice were randomly divided into 3 groups(n=15) : group NS(NS+NS), group NS+K(NS+Ketamine), group F+K(flurbiprofen axetil+Ketamine). Group F+K and group NS+K underwent intraperitoneal injection with flurbiprofen axetil or NS 30min before ketamine anesthesia lasting for 3h, whereas group NS was treated with intraperitoneal injection with NS twice. The step-through latency(STL) and error times(ETs) were tested through step-through test on the third day and the traversing platform times(TPT) and landing latency(LL) were measured by Morris water maze test 1 week later. Mice were then sacrificed and morphological changes of hippocampal CA1 region were observed. Results Compared with group NS, group NS+K presented obviously longer LL, shorter STL and increased ETs as well as decreased TPT(P<0.05).Compared with group NS+K, LL was significantly shortened while STL was remarkably extended in group F+K(P<0.05). In contrast with group NS, most of the hippocampal neurons swelled obviously and many nuclei underwent karorrhexis and karyolysis in group NS+K. Compared with group NS+K, only mild edema and slight karorrhexis were observed in group F+K. Conclusion Flurbiprofen axetil could improve memory impairment induced by ketamine in juvenile mice