Abstract: Objective: To explore the effects of self-perceived burden, self-efficacy and quality of life in myasthenia gravis patients. Methods: 116 patients with myasthenia gravis were investigated by self-perceived burden scale, self-efficacy scale and quality of life scale. Results: 83.62% of the collected patients were moderate and severe self-burden, and 68.97% of the collected patients were low level self-efficacy. There was no statistically significant difference between SPB, total score and quality of life of MG patients with different sex, P>0.05. There were statistically significant differences in different age, education, pay mode, occupation, Osserman classification, relapse and hormone shock treatment of myasthenia gravis patients between SPB, self-efficacy and quality of life, P<0.05. There was a significant negative correlation between self-perceived burden and quality of life score in patients with myasthenia gravis，P<0.05. The self-efficacy of MG patients was positively correlated with the quality of life score, P<0.05. Conclusion: During the treatment of myasthenia gravis, targeted measures should be taken to reduce the self-perceived burden of the patients, and enhance the self-efficacy of the patients, so as to improve the quality of life of myasthenia gravis patients