Abstract: Objective To compare the effect of sucralfate and pantoprazole on the prevention of antibiotic-associated diarrhea in patients with ICU mechanical ventilation. Methods Retrospective analysis of mechanical ventilation of endotracheal intubation or tube incision in the prevention of stress ulcer process in the use of sucralfate or pantoprazole cases. The sucralfate suspension was used as the experimental group. Pantonolazonana was used as a control group to compare the preventive effect of stress ulcer, the incidence of antibiotic-associated diarrhea and the long-term（30 months） survival rate of the two groups. Results There was no significant difference in the incidence of stress ulcer between the two groups(P>0.05); The incidence of antibiotic-associated diarrhea in control group was higher than that in experimental group and the difference was statistically significant(P <0.05).The long-term （30 months）survival rate of the experimental group was higher than that in the control group, and the difference was statistically significant (P <0.05).