Abstract: Objective To evaluate the application of plasma endothelin-1 (ET-1), D-dimer (D-D), plasma soluble vascular cells adhesion molecule-1 (sVCAM-1) and intercellular adhesion factor -1 (ICAM-1) in predicting the prognosis of patients with sudden deafness.Methods A total of 130 patients with sudden deafness who were admitted to Control River Hospital of Yangpu District from June 2020 to June 2022 were selected as an observation group. Meanwhile, another 120 healthy subjects who underwent physical examination were selected as a control group. Their plasma levels of ET-1, D-D, sVCAM-1 and ICAM-1 were measured by enzyme-linked immunoassay (ELISA). The value of plasma ET-1, D-D, sVCAM-1 and ICAM-1 in predicting the prognosis of these patients with sudden deafness was evaluated by receiver specific curve (ROC) analysis.Results The plasma levels of ET-1, D-D, sVCAM-1 and ICAM-1 in the observation group were significantly higher than those in the control group (P<0.05). The levels of ET-1, D-D, sVCAM-1, and ICAM-1 in patients with low-frequency sudden deafness were remarkably higher than those with high-frequency sudden deafness (P<0.05). The plasma levels of ET-1, D-D, sVCAM-1 and ICAM-1 significantly increased with the aggravation of hearing loss in patients with sudden deafness (P<0.05). Compared with the effective group, the ineffective group presented remarkably increased levels of ET-1, D-D, sVCAM-1 and ICAM-1 (P<0.05). For prognosis prediction, the sensitivity and specificity of ET-1, D-D, sVCAM-1 and ICAM-1 in combination were higher than those of each single index (P<0.05).Conclusions The increase of plasma ET-1, D-D, sVCAM-1 and ICAM-1 levels is related to the occurrence and prognosis of sudden deafness. The combined detection of the above indicators will facilitate better evaluation of the prognosis of patients with sudden deafness in clinical practice.