Abstract: Objective To explore the application and effect of personalized nutrition guidance for pregnant women during perinatal health care. Methods In this study, 240 pregnant women were divided into a control group and a research group in the outpatient clinic. In the control group, 120 pregnant women received routine obstetrics and health education; in the research group, 120 pregnant women received personalized nutrition guidance based on the control group. The status of weight gain, cesarean section rate and the impact on maternal and infant outcomes were analyzed and compared between the two groups. Results The results of weight control and maternal and infant outcomes in the study group were significantly better than those in the control group (P<0.05). Conclusions The promotion of personalized nutrition guidance during pregnancy can significantly improve the weight control of pregnant women, reduce the cesarean section rate, increase the natural delivery rate, and significantly improve the maternal and infant outcomes. It is worthy of promotion.