Comparison of the cardiovascular risk factors for coronary artery disease patients among different races

Objective To investigate the distribution of cardiovascular risk factors of coronary heart disease among different races（China and Germany）in different age groups,so as to provide support for individualized treatment. Methods Clinical data were collected from coronary heart disease patients who were newly diagnosed in our hospital（n=350）and the Affiliated Hospital of University of Ulm in Germany（n=300）from February 2016 to July 2017.The patients were divided into four groups according to their ages:＜45 years old（n=44）,45-59 years old（n=112）,60-74 years old（n=219）and ≥ 75 years old（n=275）.Furthermore,a logistic regression analysis was performed to determine the associations between cardiovascular risk factors and the severity of coronary lesions in different races.Results For the＜45 years old group,both Chinese and German patients with coronary heart disease presented significant differences in gender（P=0.019）and body mass index（BMI）（P=0.009）.For the 45-59 years old group,both Chinese and German patients with coronary heart disease presented significant differences in gender（P=0.002）,BMI（P=0.002）,C-reactive protein（CRP）（p=0.001）,total cholesterol（TC）（p=0.002）,high density lipoprotein cholesterol（HDL-C）（P=0.000）and smoking（P=0.02）.For the 60-74 years old group,both Chinese and German patients with coronary heart disease presented significant differences in BM1（P=0.000）,diabetes mellitus（P=0.007）,fasting blood glucose（P=0.000）,CRP（P=0.011）,TC（P=0.000）,triglycerides（TG）（P=0.025）,HDL-C（P=0.000）and smoking（P=0.002）.For the ≥75 years old group,significant differences were found in BMI（P=0.001）,fasting blood glucose（P=0.000）,CRP（P=0.001）,TC（P=0.000）,TG（P=0.000）,HDL-C（P=0.000）,low density lipoprotein cholesterol（LDL-C）（P=0.001）,smoking（P=0.016）and the severity of coronary artery（P=0.000）.For Chinese patients,the severity of coronary artery was related to age（P=0.012）,gender（P=0.003）,hypertension（P=0.001）and diabetes mellitus（P=0.006）.For German patients,the severity of coronary artery was related to hypertension（P=0.031）,diabetes mellitus（P=0.001）and creatinine（P=0.039）.Conclusions The cardiovascular risk factors for coronary heart disease vary among different ethnic groups（China and Germany）at different ages.Race differences may influence the association between risk factors for coronary artery disease and its pathogenesis and severity.In light of these differences,individualized treatment is required.