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LI Li, WANG Sugui, YAN Yao, HAN Zhengxiang. Expression and clinical significance of miR-197 in the serum of prostate cancer patients[J]. Journal of Xuzhou Medical University, 2019, 39(9): 691-694. DOI: 10.3969/j.issn.2096-3882.2019.09.16
Citation: LI Li, WANG Sugui, YAN Yao, HAN Zhengxiang. Expression and clinical significance of miR-197 in the serum of prostate cancer patients[J]. Journal of Xuzhou Medical University, 2019, 39(9): 691-694. DOI: 10.3969/j.issn.2096-3882.2019.09.16

Expression and clinical significance of miR-197 in the serum of prostate cancer patients

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  • Received Date: June 16, 2019
  • Revised Date: August 28, 2019
  • Objective To investigate the expression of microRNA-197 (miR-197) in the serum of prostate cancer patients and its clinical significance. Methods Real-time fluorescence quantitative polymerase chain reaction (qPCR) was used to detect the relative expression of serum miR-197 in 48 prostate cancer patients, 48 patients with benign prostatic hyperplasia and 48 healthy subjects. The relationship between the relative expression of serum miR-197 and clinicopathological characteristics was analyzed. The receiver operating characteristic (ROC) curve was plotted to analyze the sensitivity and specificity of serum miR-197 in the diagnosis of prostate cancer. Results The level of serum miR-197 in prostate cancer patients was higher than that in benign prostatic hyperplasia and healthy subjects (P<0.05). However, there was no significant difference in the level of serum miR-197 between benign prostatic hyperplasia patients and healthy subjects (P>0.05). The level of serum miR-197 was significantly correlated with clinical pathological stage, Gleason score and bone metastasis of prostate cancer (P<0.05), rather than age and prostate specific antigen (P>0.05). ROC curve showed that miR-197 could differentiate prostate cancer from benign prostatic hyperplasia and healthy subjects, with the area under the curve was 0.828 (95% CI: 0.794-0.919) and 0.809 (95% CI: 0.746-0.918), respectively. Conclusions The high expression of miR-197 in the serum of prostate cancer patients is related to the progression of prostate cancer, and can be used as a marker to determine the prognosis of prostate cancer.
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