Predictive value of neutrophil/lymphocyte and platelet/lymphocyte on patients with spontaneous circulation recovery after cardiac arrest

Objective To investigate the predictive value of peripheral bloodneutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on in-patient mortality in patients with spontaneous circulation recovery after cardiac arrest. Methods A retrospective analysis was performed using clinical data from 30 patients who recovered from cardiac arrest in the Affiliated Suzhou Hospital of Nanjing University from April 2012 to November 2018 and were admitted to the intensive care unit for more than 24 h. The patients were divided into a survival group and a death group according to the outcome of discharge. The two groups were compared for the dynamic changes and differences in NLR and PLR within 24 h and 48-72 h after admission to ICU. Multivariate analysis and ROC curve were used to explore the predictive value of NLR and PLR for in-patient mortality. Results Compared with the survival group, PLR in the death group was significantly lower within 24 h of admission to ICU (P<0.05), while NLR in 48-72 h was significantly higher (P<0.05). The NLR of the survival group within 48-72 h of admission to ICU was significantly lower than that within 24 h (P<0.05). Compared with 24 h, no statistical difference was found as to NLR and PLR in the death group within 48-72 h of admission to ICU (P>0.05). Multivariate logistic regression analysis and ROC curve showed that NLR of 48-72 h in ICU was an independent risk factor for predicting in-patient mortality, and had high sensitivity and specificity in predicting death outcomes. Conclusions NLR and PLR can be helpful to judge the outcome of patients with spontaneous circulation recovery after cardiac arrest.