Study on the relationship between high sensitive C-reactive protein level and hemoglobin level in non-dialysis chronic kidney disease

Objective To investigate the relationship between the high sensitive C-reactive (hs-CRP) protein level and hemoglobin (Hb) level in non-dialysis chronic kidney disease (CKD) patients. Methods A total of 80 non-dialysis CKD patients were divided into hs-CRP elevation group (n=38) and hs-CRP normal group (n=42) according to the hs-CRP level. The changes of renal function, Hb and hs-CRP were observed, and the correlation between hs-CRP and Hb was analyzed. Results There were no statistically significant differences in sex, age, serum creatinine (SCr), blood urea nitrogen (BUN), cystine C, estimated glomerular filtration (eGFR) and CKD stage between hs-CRP elevation group and hs-CRP normal group (P0.05). The level of Hb in the hs-CRP elevation group were lower than that in the hs-CRP normal group; the level of hs-CRP in the hs-CRP elevation group were higher than that in the hs-CRP normal group (P <0.05). There was a negative correlation between hs-CRP and Hb in the hs-CRP elevation group (r=-0.415, P=0.01). Conclusions The degree of anemia is closely related to the state of microinflammation in non-dialysis CKD patients.