Effect of preinfarction angina on remote ischemic preconditioning in patients with ST-segment elevation myocardial infarction

Objective To investigate the effect of preinfarction angina(PA) on remote ischemic preconditioning(RIPC)in patients with ST-segment elevation myocardial infarction (STEMI). Methods A total of 153 patients with acute STEMI undergoing emergency percutaneous coronary intervention in the Affiliated Hospital of Xuhou Medical University were enrolled and were randomly divided into the RIPC group and the control group. Then the patients were divided into the PA group and the non-PA group according to the existence of PA. The peak value of postoperative troponin T (Tn-T), creatine kinase isoenzyme (CK-MB) and other data after operation in each group and its subgroups were observed and statistically analyzed. Results The peak value of postoperative Tn-T and the CK-MB area under the curve in the RIPC group were significantly lower than those in the control group (P<0.01). In the RIPC group, the CK-MB area under the curve was lower in patients with PA than in patients without PA (P<0.01). Both the postoperative Tn-T peak value and the CK-MB area under the curve in the PA group were lower than those in the non-PA group (P<0.05). Either in the PA group or non-PA group, RIPC was effective in reducing the CK-MB area under the curve (P＜0.01). No interaction between RIPC and PA was observed in multiple linear regression analysis (P＞0.05). Conclusions Both the remote ischemic preconditioning and preinfarction angina can effectively reduce ischemia-reperfusion injury in acute STEMI patients. Furthermore, the protective effect of remote ischemic preconditioning on myocardial injury is not affected by preinfarction angina.