Differential detection of benign and malignant ovarian tumors by RDW, MPV and serum CA125 in peripheral blood

Objective To explore the significance of red blood cell distribution width (RDW), mean platelet volume (MPV), and cancer antigen 125 (CA125) combined detection for the differenciation of benign and malignant ovarian tumors. Methods A total of 607 patients with pelvic mass admitted to the Affiliated Hospital of Xuzhou Medical University from January 2010 to January 2019 were selected as the research subjects, including 268 patients with ovarian cancer (ovarian cancer group) and 339 patients with benign ovarian tumors (benign ovarian tumor group). The selected subjects were confirmed by pathology. A total of 200 healthy subjects in the same period were selected as the control group. The levels of CA125, RDW and MPV in the three groups were analyzed retrospectively, and the correlation between preoperative RDW and MPV and clinicopathological characteristics of patients with ovarian cancer was studied. The sensitivity and specificity of ROC curve analysis were used to identify patients with ovarian cancer and benign ovarian tumor. Results The RDW of the ovarian cancer group, benign ovarian tumor group and control group were (13.86±1.22)%, (12.82±0.83)% and (11.91±0.99)%, respectively, the difference was statistically significant (P<0.001), and the MPV of the ovarian cancer group, benign ovarian tumor group and control group were (9.29 ± 1.36) fl, (10.89±0.94) fl and (12.26±1.55)fl, respectively, the difference was statistically significant (P<0.001). The preoperative RDW level of ovarian cancer patients was positively correlated with the International Obstetrics and Gynecology Union surgical pathological stage (FIGO, 2014) (r=0.725, P=0.024), while the preoperative MPV level was negatively correlated with the FIGO stage (r=-0.831, P=0.010). The sensitivity, specificity, and AUC of RDW, MPV, and CA125 in identifying ovarian cancer and benign ovarian tumors were 83.0%, 91.2%, and 0.931 (0.907-0.955), respectively. Conclusions The combined detection of RDW, MPV and CA125 can effectively distinguish ovarian cancer and benign ovarian tumor.