Expression of macrophage migration inhibitory factor inHelicobacter pylori associated gastric mucositis

Objective To analyze the expression of macrophage migration inhibitory factor (MIF) in Helicobacter pylori (Hp)-related gastric mucosal inflammation. Methods A total of 50 patients with chronic gastritis admitted to the First Affiliated Hospital of Hunan University of Chinese Medicine from March 2017 to May 2018 were divided into Hp positive group (34 cases) and Hp negative group (16 cases) according to whether Hp infection occurred. Twenty-four patients with normal gastric mucosa were selected as the control group. The clinical data of all patients were collected and their MIF, Hp and other indicators were detected. The levels of MIF, the expression of MIF mRNA and the relationship between the degree of Hp related gastric inflammation and the expression of MIF were observed and compared. Results The MIF level, MIF positive rate, MIF mRNA expression and MIF mRNA positive rate of Hp positive group and Hp negative group were significantly higher than those of the control group. The MIF level, MIF positive rate, MIF mRNA expression and MIF mRNA positive rate of Hp positive group were significantly higher than those of Hp negative group. In Hp positive group, the MIF of mild chronic inflammation and moderate chronic inflammation were significantly higher than those of Hp negative group. The expression of MIF mRNA in mild chronic inflammation was significantly lower than that in moderate chronic inflammation (P<0.05). The expression of MIF mRNA was positively correlated with the degree of inflammation (r=0.704, P<0.05). Conclusions The level of MIF and the expression of MIF mRNA are increased in Hp infection related gastric mucosa inflammation, and increase with the aggravation of inflammation.