Effect of continuous intravenous infusion of oxycodone on pain and systemic stress response in recovery of laparoscopic pancreaticoduodenectomy operation

Objective To investigate the effect of intraoperative continuous intravenous infusion of oxycodone on pain and systemic stress response in patients undergoing laparoscopic pancreatoduodenectomy. Methods Sixty patients scheduled for laparoscopic pancreatoduodenectomy were randomly divided into 0.1 mg/kg oxycodone continuous intravenous infusion group (OCI group) and 0.1 mg/kg oxycodone intravenous injection group (OI group). Visual analogue scale (VAS) pain score and Ramsay score were used to evaluate the pain and sedation of patients immediately after extubation (T2), 5 min after extubation (T3), 15 min after extubation (T4) and leaving post-anesthesia care unit (PACU, T5). The serum levels of pituitary-target gland axis-related hormones and vasoactive hormones before anesthesia induction (T1), T2 and T3 were measured. Results At T2-T5, the visceral VAS pain score in the OCI group was lower than that in the OI group (P<0.05). At T3-T5, the Ramsay score of the OI group was significantly higher than that of the OCI group (P<0.05). At T2 and T3, the serum thyroid-stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), cortisol (Cor), norepinephrine (NE), epinephrine (E), and angiotensin Ⅱ (AT-Ⅱ) in the OCI group were significantly lower than that in the OI group (P<0.05). Conclusions Intraoperative continuous intravenous infusion of 0.1 mg/kg oxycodone can effectively relieve visceral pain and restrain systemic stress response in patients undergoing laparoscopic pancreatoduodenectomy.