Relationship between cranial imaging changes and drug treatment in patients with epilepsy

Objective To analyze the relationship between the changes of cranial imaging and the effect of drug treatment in patients with epilepsy. Methods According to the cranial imaging changes, 168 patients with newly diagnosed epilepsy were divided into three groups: normal imaging group (n=104), cortical lesion group (n=36) and non-cortical lesion group (n=28). The therapeutic effect and combined use rate of drugs in each group were analyzed retrospectively. Results The effective rates of normal image group, cortical lesion group and non-cortical lesion group were 87.50%, 47.22% and 82.14%, respectively. There was significant difference in the effective rate between the normal image group and the cortical lesion group (P<0.0166), and between the cortical lesion group and the non-cortical lesion group (P<0.0166). There was no significant difference in the effective rate between the normal image group and the non-cortical lesion group (P>0.0166). The drug combination rates of the normal image group, cortical lesion group and non-cortical lesion group were 22.12%, 77.78% and 46.43%, respectively. There was significant difference in the drug combination rates among the three groups (P<0.0166). Conclusions The imaging abnormalities of the head may be an important factor affecting the efficacy of drug treatment and the rate of drug combination in patients with epilepsy. There was no significant difference in the therapeutic effect between patients with non-cortical lesions and those with normal images, but the rate of drug combination was higher. Epilepsy patients with cortical lesions not only had a poorer therapeutic effect, but also had a higher rate of drug combination.