Clinical significance of H-FABP,NT-proBNP,hs-CRP and PCT detection for children with Mycoplasma pneumoniae pneumonia

Objective To discuss the application of combined detection of heart-type fatty acid-binding proteins (H-FABP), N-terminal pronatriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in evaluating Mycoplasma pneumoniae pneumonia (MPP). Methods A total of 125 children with pneumonia who were admitted into our hospital were enrolled. According to etiological results, they were divided into two groups: a Mycoplasma pneumonia pneumonia (MPP) group and a common bronchopneumonia (CP) group. According to disease severity, the MPP group was divided into a mild disease (CMPP) group and a severe disease (SMPP) group. Meanwhile, 50 healthy children were selected as a control group. Each group was detected for the levels of serum NT-proBNP, H-FABP, PCT and hs-CRP, and the difference of each indicator among each group was compared. ROC curve analysis was used to evaluate the efficacy of combined detection for MPP. Results The levels of H-FABP, NT-proBNP, hs-CRP and PCT in the SMPP, CMPP and CP groups were remarkably higher than those in the control group (P<0.01), while the SMPP group produced increased levels compared with the CMPP and CP Groups (P<0.01). The level of H-FABP in the CMPP group was higher than that of the CP group (P<0.01). The area under the ROC curve (AUC) was 0.815 for NT-proBNP, 0.787 for H-FABP, 0.739 for PCT and 0.743 for hs-CRP. The AUC was 0.815 when combined use of hs-CRP and PCT, and was 0.870 when combined use of NT-proBNP and H-FABP. When combined use of all four indicators, the AUC was the largest (AUC=0.957), the sensitivity was the highest (96%), and the specificity was 86%. Conclusions NT-proBNP, H-FABP, PCT and hs-CRP have certain clinical values to evaluate MPP disease. The combined use of all the four indicators can improve the evaluation efficiency of MPP severity.