Effect of Kangfuxin Solution combined with thymopentin on pulmonary tuberculosis and immune function

Objective To evaluate the clinical efficacy of Kangfuxin Solution combined with thymopentin in the treatment of pulmonary tuberculosis and its effect on the serum level of CXC motif chemokine 10 (CXCL-10). Methods From April 2015 to April 2017, 140 patients with TB-PCR positive or sputum smear positive pulmonary tuberculosis treated in Wuxi Fifth People's Hospital were selected and randomly divided into a control group and a study group (n=70 in each group). During the first two months of treatment, the study group were given thymopentin, Kangfuxin Solution, rifampin, isoniazid, ethambutol, and pyrazinamide, while the control group was given rifampin, isoniazid, ethambutol, and pyrazinamide. Two months later, the study group and the control group were treated with rifampicin and isoniazid for 4 months. The clinical effect and the incidence of adverse reactions were observed. The levels of CD8⁺, CD4⁺, CD3⁺, CD4⁺/CD8⁺ and CXCL-10 were compared between the two groups before and after treatment. Results The clinical effective rate was 88.57% in the study group and 75.71% in the control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). There was no significant difference in the levels of CD8⁺, CD4⁺, CD3⁺, CD4⁺ /CD8⁺ and CXCL-10 between the two groups before treatment (P>0.05). After treatment, the levels of CXCL-10 and CD8⁺ decreased significantly in both groups (P<0.05), with these indexes significantly lower in the study group than in the control group (P<0.05). At the same time, the levels of CD4⁺, CD3⁺, CD4⁺/CD8⁺ in the two groups increased significantly (P<0.05), with these indexes significantly higher in the study group than in the control group (P<0.05). Conclusions Kangfuxin Solution combined with thymopentin has a good clinical effect in the treatment of pulmonary tuberculosis, can significantly reduce the inflammatory response, improve the immune function, and has a high safety, which can be promoted in clinical application.