Effects of aspirin, glycine and lidocaine on acute visceral pain in mice

Objective To investigate the effects of aspirin, glycine and lidocaine on acute visceral pain in mice, so as to provide theoretical evidence for rational clinical use. Methods A total of 36 Kunming mice were randomly divided into 6 groups (n=6): a normal saline group (Group NS), an acetic acid model group (Group AA), a morphine + AA group (Group AA+Morphine), an aspirin + AA group (Group AA+Aspirin), a glycine + AA group (Group AA+Gly) and a lidocaine+ AA group (Group AA+Lidocaine). Then, a mouse model of acute visceral pain was established by intraperitoneal injection of 0.6% acetic acid. The latency and counts of acetic acid-induced writhing response were recorded. Results Intraperitoneal injection of acetic acid significantly induced acute visceral pain in mice. Compared with Group AA, mice in Groups AA+Aspirin and AA+Glycine showed significantly prolonged latency (P<0.05); mice in Groups AA+Aspirin, AA+Glycine and AA+Lidocaine showed remarkably decreased counts of writhing response (P<0.05). Conclusions Aspirin, glycine and lidocaine exert an analgesic effect against acute visceral pain in mice induced by acetic acid.