Application of dexmedetomidine combined with sufentanil in painless ultrasound gastroscopy and its influence on patients' circulatory system

Objective To study the application of dexmedetomidine combined with sufentanil in painless ultrasound gastroscopy and its influence on patients' circulatory system. Methods A total of 108 patients who underwent painless ultrasound gastroscopy in Beijing Daxing District People's Hospital from October 2016 to December 2017 were selected as the subjects of this study. All the patients were divided into a control group and a study group using random number table method, with 54 cases in each group. Patients in the control group received dexmedetomidine analgesia in common ultrasound gastroscopy, while patients in the study group received dexmedetomidine combined with sufentanil for anesthesia and analgesia during ultrasound gastroscopy. The analgesic sedative effect, the degree of pain, the changes of circulatory system and the incidence of adverse reactions before and after the examination were compared between the two groups. Results The Ramsay sedation score of the study group was higher than that of the control group, and the Visual Analogue Scale (VAS) score was lower than that of the control group (P<0.05). There were no significant differences in pulse oxygen saturation (SpO₂), heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the two groups before and after the examination (P>0.05). During the ultrasound gastroscopy, the SpO₂ of the study group was higher than that of the control group, while the HR, SBP and DBP were lower than those of the control group (P<0.05). The incidence of nausea and vomiting and total incidence of adverse reactions in the study group were lower than those in the control group, with statistical significance (P<0.05). Conclusions Dexmedetomidine combined with sufentanil is highly safe and effective in painless ultrasonic gastroscopy. It can enhance the analgesic and sedative effect and maintain the stability of the circulatory system, which is worthy of clinical promotion.