Effects of Huoxue Huayu Recipe combined with Xiaozhi San on ER, PR, survivin and Bcl-2 in Uygur ethnic minority patients with endometrial polyps and its relationship with postoperative recurrence

Objective To observe the effects of Huoxue Huayu Recipe combined with Xiaozhi San on estrogen receptor (ER), progestron receptor (PR), survivin and B-cell lymphoma-2 (Bcl-2) in Uygur ethnic minority patients with endometrial polyps and its relationship with postoperative recurrence. Methods A total of 123 Uygur ethnic minority patients were enrolled, who were diagnosed with bloody endometrial polyps in Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from March 2016 to December 2017. They were randomly divided into two groups: a Chinese medicine group (n=62) and a Western medicine group (n=61). After operation, the Chinese medicine group was orally administrated with Huoxue Huayu decoction and treated with Xiaozheng San. The Western medicine group was orally treated with desogestrel and ethinylestradiol tablets for three months. Both groups were compared for their Chinese medicine syndrome scores, the levels of ER, PR, survivin and Bcl-2 and the recurrence rate of endometrial polyps one year after surgery. Results After treatment, the Chinese medicine group presented remarkably lower scores of Chinese medicine syndrome than the Western medicine group (P＜0.01). After treatment, there was no difference in the expression of EP between the two groups, while the level of PR significantly increased in the Chinese medicine group compared with those in the Western medicine group (P＜0.01). The Chinese medicine group produced relatively lower levels of survivin and Bcl-2 mRNA than the Western medicine group, and the recurrence rate of endometrial polyps was in the Chinese medicine group (4.8%) was markedly lower than that in the Western medicine group (16.4%). Conclusions The combined use of Huoxue Huayu Recipe and Xiaozheng San can effectively improve the clinical symptoms of Uygur ethic minority EP patients, which may be related with its effects on the expression of PR, survivin and Bcl-2, so as to reduce the recurrence of endometrial polyps.