Correlation analysis of tumor budding on clinicopathological characteristics and prognosis of colorectal cancer

ob＜x＞jective: To explore the relationship between tumor budding and clinicopathological characteristics of colorectal cancer, and to study the influence of tumor budding on the prognosis of patients with colorectal cancer, so as to provide a new direction for clinical diagnosis, treatment and prognosis evaluation of colorectal cancer. Methods: 285 cases of colorectal cancer without radiotherapy and chemotherapy from January 201 5 to December 2015 in the Department of Gastroenterology, Affiliated Hospital of Xuzhou Medical University were selected as the research ob＜x＞ject. According to the level of tumor budding, they were divided into low budding group and high budding group. The relationship between tumor budding and clinical pathological characteristics of colorectal cancer was analyzed; the relationship between tumor budding and tumor prognosis was analyzed in follow-up patients. Results: the proportion of patients with low histological grade, invasion type, high depth of invasion and recurrence in the high tumor budding group was significantly higher than that in the low tumor budding group, and the difference was statistically significant(P<0.05); multivariate Cox regression analysis showed that tumor budding was the independent risk factor for the prognosis of colorectal cancer patients (HR=2.663, 95%CI：1.534~3.878, P<0.001). Conclusion: tumor budding is related to the invasion of colorectal cancer. Tumor budding is an important risk factor for the prognosis of colorectal cancer patients.