Effects of borneol on the pharmacokinetics of gemcitabine in 9Lacz cell-bearing rats

Objective To investigate the effects of borneol on the pharmacokinetics of gemcitabine in 9Lacz cell-bearing rats. Methods A rat model of glioma was established using 9Lacz cells. The modeled rats were randomly divided into three groups: a gemcitabine group (150 mg/kg gemcitabine), a vehicle control group (150 mg/kg gemcitabine+2 ml vehicle), and a gemcitabine combined with borneol group (150 mg/kg gemcitabine+300 mg/kg borneol). Then,the microdialysis sampling method was used to collect microdialysis solution around the brain tumor at different time points, where the concentration of gemcitabine was detected by UPLC-MS/MS. The pharmacokinetic parameters were calculated. Results The gemcitabine and borneol group presented remarkable increases in the values of t_1/2、AUC_(0-∞) and C_max, compared with the gemcitabine group (P＜0.01). Conclusions Borneol can improve the bioavailability of gemcitabine in 9Lacz cell-bearing rats.