Clinical characteristics of 119 thymomas

Objective To investigate the relationship between the onset age of thymoma, tumor size, Ki-67 positive rate, CYFRA21-1, neutrophil to lymphocyte count ratio (NLR), neutrophil, lymphocyte, eosinophil counts and thymoma WHO pathological type and Masaoka stage, so as to better determine the malignancy of thymoma and guide further treatment. Methods A total of 119 patients with thymoma who were diagnosed in the Affiliated Hospital of Xuzhou Medical University from December 2014 to September 2020 were enrolled and their clinical data were retrospectively analyzed. The relationship between the onset age of thymoma, tumor size, Ki-67 positive rate, CYFRA21-1, NLR, neutrophil, lymphocyte, eosinophil counts and thymoma WHO pathological type (benign and malignant) and Masaoka stage (early and advanced) were analyzed. Results The distribution of WHO pathological type (benign and malignant) in Masaoka stage (early and advanced) was not statistically different (P＞0.05). There was no statistical difference between male and female in the onset age of thymoma, tumor size, Ki-67 positive rate, CYFRA21-1, WHO pathological type (benign and malignant) and Masaoka stage (early and advanced) (P＞0.05). The onset age and the positive rate of Ki-67 were significantly different in benign and malignant thymoma (P<0.05). Tumor size and CYFRA21-1 were significantly different between early and advanced thymoma (P<0.05). Conclusions Sex is not the factor that determines the clinical characteristics of thymoma. The malignancy of thymoma can be assessed through measurement of the positive rate of Ki-67 and CYFRA21-1.