Association between hepatic steatosis index and impaired fasting glucose risk in community population

Objective To explore the correlation between hepatic steatosis index (HSI) and impaired fasting glucose (IFG) in community population, and evaluate the predictive value of HSI in the risk of IFG. Methods A total of 1 064 adults, who performed physical examinations in Xuzhou Central Hospital in 2010 were selected. Their anthropometric and biochemical indicators were collected, and HSI was calculated. According to their baseline HIS, the subjects were divided into four groups. During the following-up visits over six years, their blood glucose were measured, and the presence of IFG was regarded as the end point of observation. The predictive value of HIS towards IFG was assessed. Results During the following-up visits, the cumulative incidence of IFG was significantly higher in the Q4 group than that in the Q1 group (P<0.01). After adjustment for metabolic factors, the risk of IFG in the Q4 group still significantly increased compared with the Q1 group, with an relative ratio(RR) of 2.141 and a 95% confidence interval of 1.336-3.431(P<0.01). The predicted values of HSI were highly consistent with the obtained indexes, with the same data distribution (χ²=7.001,P=0.536). Additionally, ROC curve analysis indicated that HSI can be used to predict the risk of IFG (AUC = 0.645, 95% CI: 0.615-0.674, Z=6.878,P<0.01). Conclusions There is significantly positive correlation between HSI and IFG and HIS is an independent risk factor for IFG. HSI can be used as a potential predictor of IFG.