Advanced Search
LI Yutao, LIU Ningsa, LI Hujun, XU Kailin, LI Zhenyu. Prognostic values of platelet distribution width-to-platelet count ratio for multiple myeloma[J]. Journal of Xuzhou Medical University, 2021, 41(7): 493-498. DOI: 10.3969/j.issn.2096-3882.2021.07.005
Citation: LI Yutao, LIU Ningsa, LI Hujun, XU Kailin, LI Zhenyu. Prognostic values of platelet distribution width-to-platelet count ratio for multiple myeloma[J]. Journal of Xuzhou Medical University, 2021, 41(7): 493-498. DOI: 10.3969/j.issn.2096-3882.2021.07.005

Prognostic values of platelet distribution width-to-platelet count ratio for multiple myeloma

More Information
  • Received Date: March 21, 2021
  • Revised Date: June 05, 2021
  • Objective To investigate the relationship between platelet distribution width-to-platelet count ratio (PDW/PLT) in peripheral blood ard the clinical characteristics and prognosis of patients with multiple myeloma (MM). Methods A total of 155 MM patients who were admitted to the Affiliated Hospital of Xuzhou Medical University from February 1, 2013 to June 30, 2019 were enrolled and their clinical data were collected. According to the optimal cut-off value of PDW/PLT, they were divided into two groups: a high PDW/PLT group (PDW/PLT≥0.066) and a low PDW/PLT group (PDW/PLT<0.066). Both groups were compared for clinical characteristics, effectiveness and prognosis. Results Statistical differences were found in age (P=0.010), Durie Salmon (DS) stages (P=0.003), International Staging System (ISS) stages (P=0.003), hemoglobin (Hb) (P=0.039), platelets (PLT) (P=0.000), serum creatinine (Scr) (P=0.002), serum calcium (Ca) (P=0.041), β2-microglobulin (β2-MG) (P=0.001), lactate dehydrogenase (LDH) (P=0.004), and the degree of remission (P=0.002) between the high PDW/PLT group and the low PDW/PLT group. Univariate survival analysis results showed that DS stage Ⅲ, ISS stage Ⅲ, Hb<100 g/L, albumin (Alb)<35 g/L, LDH≥250 U/L, β2-MG≥5.5 mg/L, PDW/PLT≥0.066 and ineffective remission were the factors affecting the prognosis of MM patients. Furthermore, multivariate analysis showed that PDW/PLT≥0.066, LDH≥250 U/L, and ineffective remission were the independent prognostic factors affecting OS in MM patients. Conclusions Peripheral blood PDW/PLT≥0.066 at the first diagnosis is related to the shortened survival time of MM patients. It suggests that peripheral blood PDW/PLT may be used as a new indicator, which if used in combined with current prognostic indicators can better predict the prognosis of MM patients.
  • [1]
    Moreau P,Attal M,Facon T.Frontline therapy of multiple myeloma [J].Blood,2015,125(20):3076-3084.
    [2]
    Nishida H,Yamada T.Monoclonal antibody therapies in multiple myeloma:a challenge to develop novel targets[J/OL].J Oncol,20019,2019:6084012.
    [3]
    Pratt G.An oral proteasome inhibitor for multiple myeloma[J].Lancet Oncol,2014,15(13):1417-1418.
    [4]
    Takeuchi H,Abe M,Takumi Y,et al.The prognostic impact of the platelet distribution width-to-platelet count ratio in patients with breast cancer[J/OL].PLoS One,2017,12(12):e0189166.
    [5]
    侯铁伟,单永琪,张成.术前血小板分布宽度/血小板计数对结直肠癌患者手术预后评价价值研究 [J].临床军医杂志,2020,48(9):1052-1055.
    [6]
    中国医师协会血液科医师分会,中华医学会血液学分会,中国医师协会多发性骨髓瘤专业委员会.中国多发性骨髓瘤诊治指南(2015年修订) [J].中华内科杂志,2015,54(12):1066-1070.
    [7]
    Kumar S,Paiva B,Anderson KC,et al.International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma [J].Lancet Oncol,2016,17(8):e328-e346.
    [8]
    Goubran HA,Stakiw J,Radosevic M,et al.Platelets effects on tumor growth [J].Semin Oncol,2014,41(3):359-369.
    [9]
    Xu XR,Yousef GM,Ni H.Cancer and platelet crosstalk:opportunities and challenges for aspirin and other antiplatelet agents[J].Blood,2018,131(16):1777-1789.
    [10]
    Kyle RA,Gertz MA,Witzig TE,et al.Review of 1027 patients with newly diagnosed multiple myeloma [J].Mayo Clin Proc,2003,78(1):21-33.
    [11]
    Tao ZF,Fu WJ,Yuan ZG.et a1.Prognostic factors and staging systems of multiple myeloma [J].Chin Med J (Engl),2007,120(19):1655-1658.
    [12]
    崔壮壮,张媛媛,金北平,等.中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对初诊多发性骨髓瘤患者总生存和无进展生存的预测意义[J].解放军医学院报,2019,40(2):121-126.
    [13]
    Song Q,Wu JZ,Wang S,et al.Elevated preoperative platelet distribution width predicts poor prognosis in esophageal squamous cell carcinoma [J/OL].Sci Rep,2019,23,9(1):15234.
    [14]
    吴佳成,翟宝茜,姜力.术前血小板分布宽度与血小板计数比值对膀胱癌术后患者预后评估价值研究[J].临床军医杂志,2020,48(11):1363-1365.
    [15]
    王玉闽,赵红,李伟男.急性失血输血前后及肺癌化疗前后的红细胞和血小板分布宽度比较 [J].中国冶金工业医学杂志,1995,(5):269-270.

Catalog

    Article views (737) PDF downloads (695) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return