Effect of intrauterine EGF perfusion on pregnancy outcome improvement in patients with mild intrauterine adhesions during frozen-thawed embryo transfer

Objective To evaluate the effect of intrauterine perfusion (IUA) of epidermal growth factor (EGF) on pregnancy outcome improvement in patients with mild intrauterine adhesions during frozen-thawed embryo transfer. Methods A total of 48 mild IUA patients were enrolled, who were admitted into Xuzhou Central Hospital from March 2018 to September 2019, and waiting for frozen-thawed embryo transfer after in vitro fertilization (IVF) and whole embryo freezing in a fresh cycle. They were randomly divided into two groups: a control group and a test group. Patients in the control group were infused with normal saline, while those in the test group was infused with EGF. Both groups were compared with thickness, type and blood flow of the endometrium, and their implantation rate, spontaneous abortion rate, biochemical pregnancy rate and clinical pregnancy rate were recorded. Results After intrauterine infusion, a remarkably increased thickness in the test group (9.39±1.92)mm than the control group (8.23±1.2) mm, P<0.05. The test group showed obvious improvement in endometrium type, and an increased percentage of type A endometrium, without statistical difference (P>0.05). No significant changes were observed in the test group as to blood flow of the endometrium after treatment (P>0.05). During the follow-up visits, the test group showed increases in the implantation rate and clinical pregnancy rate, compared with the control group (P<0.05), while no significant difference was found in the rate of early abortion, multiple pregnancy and ectopic pregnancy. Conclusions Intrauterine infusion of EGF can improve endometrial thickness, so as to improve receptivity, increase clinical pregnancy rate and improve the pregnancy outcome of mild IUA patients.