Correlations of serum HDL and UA with early neurological improvement and symptomatic intracranial hemorrhage in patients with cerebral infarction after mechanical thrombectomy

Objective To explore the correlations of serum high density lipoprotein (HDL) and uric acid (UA) with early neurological improvement (ENI) and symptomatic intracranial hemorrhage (sICH) in patients with acute cerebral infarction after mechanical thrombectomy. Methods A total of 553 patients with cerebral infarction who received intravascular mechanical thrombectomy were retrospectively analyzed. Their National Institutes of Health Stroke Scale (NIHSS) scores, occurrence of sICH and other baseline information were recorded. According to the difference in NIHSS scores between admission time and 24 h after thrombectomy, the patients were divided into two groups: a good ENI group and a poor ENI group. Multivariate logistic regression was used to determine the independent factors of ENI and sICH. Results The good ENI group presented remarkable increases in serum HDL and UA, compared with the poor ENI group (P<0.05). The level of serum UA was obviously higher in the non-sICH group than that in the sICH group (P<0.05). However, serum HDL was not the influencing factor of sICH (P＞0.05). Conclusions High serum HDL and UA are the independent protective factors of ENI in patients with cerebral infarction after mechanical thrombectomy, and high serum UA may reduce the incidence of sICH.