Evaluation of serologic anti-nuclear antibody detection among women with polycystic ovary syndrome
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Abstract
Objective Polycystic ovary syndrome (PCOS) is a common metabolic reproductive syndrome in women of childbearing age. Autoimmune antibodies may be involved in the pathogenesis of PCOS. The current study was designed to evaluate the detection of antinuclear antibody (ANA) in PCOS patients. Methods A total of 52 PCOS patients who were admitted to Clinical Center of Reproductive Medicine, Xuzhou Central Hospital from January to September 2020 were enrolled. Meanwhile 67 patients who were admitted due to male factors or fallopian tube factors alone were set as a normal control group. Their levels of ANA were detected by immunofluorescence method. The correlation between ANA and PCOS was analyzed by Spearman rank method. Results The positive rate of ANA in the PCOS group was higher than that in the control group (15.38% vs 4.48%, P=0.042). After correction of age and BMI, the positive rate of ANA in the PCOS group was positively correlated with fasting insulin (Fins) and homeostasis model assessment for insulin resistance (HOMA-IR), without obvious relationship with androgen and lipid metabolism. Conclusions PCOCS patients childbearing age is associated with ANA, and the increases in the ANA positive rate is associated with glucose metabolism. The autoimmune process may exist in the pathogenesis of PCOS.
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