Expression of miR-210-3p in lung cancer tissues and its effect on prognosis

Objective To evaluate the expression of miR-210-3p in lung cancer tissues and its effect on prognosis. Methods A total of 187 lung cancer patients who were diagnosed in the First Hospital of Handan from February 2012 to December 2017 were enrolled and their clinical data were retrospectively analyzed. The relative expression of miR-210-3p in lung cancer tissues and adjacent normal tissues were compared, and the relationship between the relative expression of miR-210-3p and various clinicopathological data of patients was analyzed. Meanwhile, the survival curve of patients was statistically analyzed. Results The relative expression of miR-210-3p in lung cancer tissues was significantly higher than that in adjacent normal tissues (P<0.05). The expression of miR-210-3p was related to the clinical classification and lymph node metastasis of lung cancer (P<0.05), without relationship with sex, age, smoking history, lung cancer tissue type and tumor tissue sizes (P>0.05). Lung cancer patients with clinical stage of Ⅲ/Ⅳ, lymph node metastasis showed higher levels of miR-210-3p than those with clinical stage of Ⅰ/Ⅱ, without lymph node metastasis (P<0.05). With the increase in miR-210-3p expression, the survival rates of lung cancer patients significantly decreased (P<0.05). Conclusions The relative expression of miR-210-3p in lung cancer tissues is higher than that in adjacent normal tissues. The expression of miR-210-3p is related to the clinical classification and lymph node metastasis of lung cancer.