Expression of PR, DPT and TGF-β1 in endometrial carcinoma and their correlation

Objective To analyze the relationship between the expression of progesterone receptor (PR), dermatopontin (DPT) and transformation growth factor β1(TGF-β1) and the clinicopathological characteristics of endometrial carcinoma (EC). Methods A total of 80 patients with EC, and 30 patients with atypical hyperplasia endometrial disease and 30 patients with normal hyperplasia endometrial tissue who were diagnosed in Pizhou Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from September 2013 to April 2016 were enrolled. The expression and distribution of PR, DPT and TGF-β1 was determined by immunohistochemistry (SP method) using EC tissue, atypical hyperplasia endometrial tissue and normal hyperplasia endometrial tissue. The relationship between the expression of PR, DPT and TGF-β1 and the clinicopathological characteristics of endometrial cancer patients was analyzed. Furthermore, the correlation between the expression of PR, DPT and TGF-β1 was also analyzed. Results The positive expression rates of PR, DPT and TGF-β1 in EC, atypical hyperplasia endometrial tissue were significantly different from those in normal endometrial tissue (P<0.05). The positive expression rates of PR and DPT were the lowest in EC, while TGF-β1 expression was the highest in EC. PR protein was localized in the nucleus and cytoplasm, while DPT and TGF-β proteins were localized in the cytoplasm. The expression of PR in EC tissue was significantly different in histological grade, myometrial invasion depth and lymph node metastasis (P<0.05).The expression of DPT was significantly different in histological grade and lymph node metastasis (P<0.05).The expression of TGF-β1 was significantly different in histological grade, pathological stage and myometrial depth (P<0.05). Further correlation analysis found that the expression of PR was positively correlated with DPT (r=0.28, P<0.05), while the expression of PR was negatively correlated with TGF-β1(r=-0.224, P<0.05). Conclusions The positive expression rate of PR and DPT is the lowest, while the positive expression rate of TGF-β1 is the highest. The expression of PR is positively correlated with DPT, but negatively correlated with TGF-β1. These three proteins can effectively reflect the occurrence and development of endometrial lesions.