Application of PGT-A in assisted reproductive therapy for patients with recurrent pregnancy loss or advanced maternal age
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YUAN Mu,
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ZHANG Rongrong,
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SONG Xuemei,
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YUAN Zhenya,
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ZHU Tong,
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LI Yuwen,
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CAI Qian,
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HUANG Xiaojie,
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BAI Mingzhu,
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ZHANG Zhenbo,
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FNEG Youji
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Abstract
Objective To investigate whether preimplantation genetic testing for aneuploidy (PGT-A) improves the pregnancy outcomes for patients with recurrent pregnancy loss (RPL) or advanced maternal age after in vitro fertilization (IVF). Methods Patients with RPL or advanced maternal age (≥35 years old) who underwent PGT-A in the Assisted Reproduction Center of Xuzhou Maternal and Child Health Hospital from January 2019 to January 2021 were selected and their clinical data were retrospectively analyzed. PGT-A was adopted to detect blastocyst chromosomal ploidy. The pregnancy outcomes of each group were compared after single euploid blastocyst transfer. Results This study included PGT-A cycles in IVF patients with RPL (n=52), those with advanced maternal age (n=50), as well as non-PGT-A cycles in patients with RPL (n=23) and those with advanced maternal age (n=381). For PRL patients, there was no statistical difference in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, and clinical abortion rate between the PGT-A group and the control group (P>0.05). However, the PGT-A group showed a decreased tend in the ongoing pregnancy rate. There was no significant difference in pregnancy outcomes between the two groups after age stratification at the age of 35. Compared with the control group, the PGT-A group presented remarkable decreases in embryo implantation rate, biochemical pregnancy rate, clinical pregnancy rate and ongoing pregnancy rate in patients with advanced maternal (P<0.05). Moreover, with the rise in age, PGT-A had a more obvious effect on the improvement of pregnancy rate by IVF, and on the reduction of abortion rate in patients with advanced maternal age. Conclusions PGT-A can prevent the implantation of aneuploid blastocyst and improve IVF pregnancy outcome in patients with advanced maternal age, without good effect on that of patients with RPL.
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