Clinical value of PCIS combined with UA and Hcy in the diagnosis of children with sepsis associated encephalopathy

Objective To investigate the value of pediatric critical illness score (PCIS), uric acid (UA) and homocysteine (Hcy) in the diagnosis of children with sepsis associated encephalopathy (SAE). Methods A total of 267 children with sepsis who were admitted to the Pediatric Intensive Care Unit (PICU), Xuzhou Children's Hospital from February 2019 to February 2022 were enrolled and their clinical data were retrospectively analyzed. They were divided into two groups: a SAE group (n=90) and a non-SAE group (n=177). The two groups were compared for general data and related indicators, and the risk factors of SAE were analyzed. A receiver operating characteristic curve (ROC) was plotted to determine the sensitivity, specificity and cut-off value of PCIS, UA and Hcy in the diagnosis of SAE in children. Results The AUC value of PCIS combined with UA and Hcy in the diagnosis of SAE was 0.981, with a sensitivity of 96.67%, and a specificity of 89.27%, with statistical difference (P<0.05). Conclusions PCIS, UA and Hcy are valuable in the diagnosis of SAE in children.