Advances in the study of tumor-associated macrophages in the immune microenvironment of diffuse large B-cell lymphoma

Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of lymphoma. Tumor-associated macrophages (TAMs) have emerged as crucial components of the tumor microenvironment (TME), exerting a series of effects that promote the growth and proliferation of DLBCL, facilitating evasion from the host immune system, and reducing overall survival. Given the significance of TAMs in DLBCL, this article provides a brief review of the current study on the role of TAMs in the immune microenvironment of DLBCL, including briefly summarization of the formation and classification of TAMs, phenotypic conversion from M2 to M1 as well as the mechanisms of related factors, and prognostic implications. Furthermore, it briefly discusses the molecular targeted therapies and new drugs related to TAMs.