Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice

ZHOU Han; XU Xiangying; WU Feng; ZHANG Jiayi; SHEN Yajing; ZHANG Wei; JI Jingjing; ZHOU Ya; WANG Dan

Journal of Xuzhou Medical University > 2017 > 37(6): 369-371.

ZHOU Han, XU Xiangying, WU Feng, ZHANG Jiayi, SHEN Yajing, ZHANG Wei, JI Jingjing, ZHOU Ya, WANG Dan. Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice[J]. Journal of Xuzhou Medical University, 2017, 37(6): 369-371.

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Effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice

1.
Grade 2013, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China
2.
Department of Anesthetic Pharmacology, Xuzhou Medical University

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Published Date: June 24, 2017

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Objective To observe the effects of Tianshu capsules on the memory impairment induced by formaldehyde in mice. Methods Mice were randomly divided into five groups: a normal saline group (Group NS), a formaldehyde group (Group FA), a low dose of Tianshu capsule (0.3 g·kg-1) group (Group CLL), a middle dose of Tianshu capsule (0.6 g·kg-1) group (Group CLM), and a high dose of Tianshu capsule (1.2 g·kg-1) group (Group CLH). The latency and number of errors in mice were observed by the step-through test. Results Compared with Group NS, Group FA presented obviously shorter latency (P<0.05) and an increased number of errors (P<0.01). Compared with Group FA, the latency was remarkably extended in Group CLH (P<0.01), while the number of errors was marked decreased for Groups CLL, CLM and CLH (P<0.01). Conclusions Tianshu capsules can improve the memory impairment induced by formaldehyde in mice.
- formaldehyde,
- Tianshu capsule,
- step-through test,
- memory

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[1]	王小玲,原福胜,张志红,等.甲醛吸入对小鼠学习记忆能力的影响[J]. 环境与健康杂志,2008,25(5):400-402.
[2]	施健,童智敏,姜荣明.职业接触甲醛对工人神经行为功能的影响[J]. 环境与职业医学,2007,24(6):609-610.
[3]	方雄,李强,雷海民.川芎天麻药对的化学成分及其药理作用研究概述[C]. 中华中医药学会中药化学分会第六届（2011）学术年会论文集.长沙:中华中医药学会中药化学分会,2011:266-271.
[4]	王鸿,原福胜,王君霞,等.甲醛和甲苯联合染毒致小鼠脑组织氧化损伤作用[J]. 中国公共卫生,2011,27(10):1289-1291.
[5]	段丽菊,王晓平,严彦,等.NO在甲醛介导的氧化损伤中的协同作用[J]. 环境科学学报,2006,26(3):505-508.
[6]	白飞,宋立明,杨兆祥,等.天麻素及天麻苷元结构修饰研究进展[J]. 化学试剂,2014,36(5):419-422.
[7]	赵文红,邓泽元,范亚苇,等.阿魏酸体外抗氧化作用研究[J]. 食品科学,2010,31(1):219-223.
[8]	张勤,杨天华,周沐科,等.天舒胶囊对偏头痛动物模型血浆一氧化氮、一氧化氮合酶、降钙素基因相关肽含量及血流动力学的影响[J]. 临床神经病学杂志,2008,21(4):695-699.
[9]	于剑奇,陈勤,陈逸青,等.阿魏酸对颅脑损伤小鼠脑组织的保护作用[J]. 中国医院药学杂志,2014,34(8):612-616.

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