Effects of ulinastatin on the hemodynamics and pulmonary oxygenation function of elderly patients during total hip arthroplasty

Objective To explore the effects of ulinastatin on the hemodynamics and pulmonary oxygenation function of elderly patients during total hip arthroplasty. MethodsA total of 40 patients who underwent cemented total hip arthroplasty were randomly divided into two groups: an ulinastatin group (Group U) and a control group (Group C) (n=20). Then, the following indexes were recorded when the operation began (T1), when an acetabular prosthesis was inserted (T2), when the femur was reamed (T3), when bone cement was implanted (T4), when the femoral prosthesis was inserted (T5), when the hip was relocated (T6) and at the end of operation (T7): cardiac output (CO), cardiac index(CI), stroke volume (SV), stroke volume index (SVI), mean arterial pressure (MAP), heart rate (HR), electrocardiogram (ECG), pulse oxygen saturation (SpO2), entropy index (RE/SE) and other parameters. Meanwhile, blood gas analysis was performed and the changes of partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) were recorded at T1, T3, T5, T6 and T7. ResultsCompared with the results at T1, both Groups U and C presented remarkable decreases in CO, CI, SV, SVI and MAP at T3, T4, T5, T6 and T7 (P<0.05). Compared with Group C, marked differences were found in CO, CI, SV, SVI and MAP for Group U at T5 and T6 (P<0.05). No significant difference was found as to HR between the two group (P>0.05). The total dose of phenylephrine used in Group U during the operation was significantly lower than that in Group C (P<0.05). Compared with the results at T1, Group C presented remarkable decreases in PaO2 at T3, T5, T6 and T7 (P<0.05), while Group U showed markedly decreased PaO2 at T5, T6 and T7 (P<0.05). Compared with Group C, significant differences were found as to PaO2 for Group U at T5 and T6 (P<0.05). There was no significant change in PaCO2 between the two groups (P>0.05). ConclusionsUlinastatin can stablize the hemodynamics of elderly patients during total hip arthroplasty and protect the pulmonary oxygenation function in patients.