Effects of dexmedetomidine combined with dezocine in elderly patients during diagnostic curettage

Objective To evaluate the effects of dexmedetomidine combined with dezocine in elderly patients undergoing dilatation and curettage. MethodsA total of 40 elderly patients (70-83years older) undergoing dilatation and curettage were selected and randomly divided into two groups: group D (dexmedetomidine group) and group P (propofol group),with 20 patients in each group. The patients in group D were received dexmedetomidine(0.8 μg /kg, the infusion time was set to 10 min and the maintenance dose of dexmedetomidine injection was 0.5 μg/(kg·h), dezocine 0.1 mg/kg .The patients in group P were received propofol 1.5 mg/kg (maintenance dose of propofol was 3-6 mg/(kg·h) and dezocine 0.1 mg/kg. The mean arterial pressure (MBP), heart rate (HR) and SpO2 of the two groups were recorded before anesthesia (T0), when OAA/S ＝3 (T1), when cervical dilation started (T2) and after surgery (T3). Meanwhile, respiratory depression, glossoptosis, intraoperative awareness, sedation scores and OAA/S scores during the awaking period were also recorded. ResultsGroup D showed more stable blood pressure, a less incidence rate of respiratory depression and glossoptosis than Group P (P<0.05). Intraoperative awareness did not happen in both group, while patients in Group D showed better awareness than those in Group P (P<0.05). ConclusionIt is safe and effective to use dexmedetomidine combined with dezocine in elderly patients during diagnostic and curettage.