Effects of bromocriptine on experimental gastric ulcer in mice

Objective To observe the effects of bromocriptine on experimental gastric ulcer in mice. MethodsWater immersion restraint method: Mice were randomly divided into three groups (n=10): a control group (Group C), a water immersion restraint model group (Group W) and a bromocriptine prevention group (Group Brc + W). Mice in the Group Brc+W were pretreated with 2.5 mg·kg-1 bromocriptine through intragastric administration, and half an hour later received water immersion restraint with Group W. Then, 9 hours later, their visceral pain index and gastric ulcer index were measured. Aspirin method: Mice were randomly divided into three groups (n=10): a control group (Group C), an aspirin model group (Group Asp) and a bromocriptine prevention group (Group Brc+Asp). Mice in the Group Brc+Asp were pretreated with 2.5 mg·kg-1 bromocriptine through intragastric administration, and half an hour later given 300 mg·kg-1 aspirin through intragastric administration with Group Asp. Then, 1 hour later, their visceral pain index and gastric ulcer index were measured. ResultsWater immersion restraint method: Compared with the C group, the visceral pain index and gastric ulcer index were significantly increased in the W group (P<0.01). Compared with the W group, the visceral pain index and gastric ulcer index were significantly decreased in the Brc+W group (P<0.01). Aspirin method: Compared with the C group, the visceral pain index and gastric ulcer index were significantly increased in the Asp group (P<0.01). Compared with the Asp group, the visceral pain index and gastric ulcer index were significantly decreased in the Brc+Asp group (P<0.01). Conclusions Pretreatment with bromocriptine has protective effects on gastric ulcers induced by water immersion restraint and aspirin.