impacts of the down-regulation of IFG diagnostic cut-point on brachial artery endothelial function and carotid intima-media thickness

Objective To observe the changes of brachial artery endothelial function and carotid intima-media thickness (CIMT) in patients with impaired fasting glycaemia(IFG). Methods Subjects from normal oral glucose tolerance test (OGTT) and pure IFG population were divided into three groups by fasting plasma glucose (FPG) level: group A（FPG: 3.9～5.6mmol/L）, group B（FPG: 5.6～6.1mmol/L）, group C（FPG: 6.1～6.9mmol/L）. FPG, FINS, glycosylated hemoglobin (HbA1c), blood lipids?(TC, TG, LDL-C, HDL-C), high sensitivity C-reactive protein(hs-CRP) and cystatin C(CysC) were measured after overnight fast. 2hPG and 2hINS were measured on two hours of OGTT. Ultrasound evaluation was conducted on the brachial artery endothelium dependent dilation function(EDD) and CIMT. These indicators were compared among the 3 groups. Results Compared with group A, EDD of group B and group C were decreased(P<0.01), but the differences of EDD between group B and group C were not statistically significant(P>0.05). The differences of CIMT among the three groups were not statistically significant(P>0.05). Conclusion The down-regulation of IFG diagnostic cut-point is conducive to the detection of early arteriosclerosis