Effect of Flurbiprofen Axetil on Memory Impairment Induced by Ketamine in Juvenile Mice

Objective To observe the effect of flurbiprofen axetil on memory impairment induced by ketamine in juvenile mice. Methods Mice were randomly divided into 3 groups(n=15) : group NS(NS+NS), group NS+K(NS+Ketamine), group F+K(flurbiprofen axetil+Ketamine). Group F+K and group NS+K underwent intraperitoneal injection with flurbiprofen axetil or NS 30min before ketamine anesthesia lasting for 3h, whereas group NS was treated with intraperitoneal injection with NS twice. The step-through latency(STL) and error times(ETs) were tested through step-through test on the third day and the traversing platform times(TPT) and landing latency(LL) were measured by Morris water maze test 1 week later. Mice were then sacrificed and morphological changes of hippocampal CA1 region were observed. Results Compared with group NS, group NS+K presented obviously longer LL, shorter STL and increased ETs as well as decreased TPT(P<0.05).Compared with group NS+K, LL was significantly shortened while STL was remarkably extended in group F+K(P<0.05). In contrast with group NS, most of the hippocampal neurons swelled obviously and many nuclei underwent karorrhexis and karyolysis in group NS+K. Compared with group NS+K, only mild edema and slight karorrhexis were observed in group F+K. Conclusion Flurbiprofen axetil could improve memory impairment induced by ketamine in juvenile mice